Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Microglial Priming in Alzheimer’s Disease

Alzheimer’s disease (AD) is one of the most common types of dementia among older adults. Research studies have demonstrated that pathological changes in the human brain, whether directly or indirectly, can ultimately cause loss of synaptic function, mitochondrial damage, microglial cell activation, and neuronal cell death. However, the pathogenesis of AD is not yet fully understood and there is currently no definitive treatment for the neurological disease. Research studies have demonstrated that the activation and priming of microglial cells may contribute to the pathogenesis of AD.  

 

A proinflammatory status of the central nervous system (CNS) can also cause changes in the function of the microglial cells or microglia. Neuroinflammation is closely associated with the activation of microglia and astrocytes which are connected to a variety of neurological diseases by the synthesis and secretion of inflammatory mediators such as iNOS, ROS, and proinflammatory cytokines. According to research studies, microglial priming is also caused by the inflammation of the CNS.  

 

Therefore, whether microglial priming is the result or the cause of neuroinflammation is still controversial. Microglial cell activation commonly causes an increase of Aβ and tau proteins as well as a decrease of neurotrophic factors, ultimately leading to the loss of healthy brain cells or neurons and the development of neuritic plaques and neurofibrillary tangles which are closely associated with AD. With the progression of Alzheimer’s disease, changes from neuronal dysfunctions which may have no obvious symptoms to memory loss and cognitive impairment may become more noticeable.  

 

Microglial Priming, Neuroinflammation, and AD

 

Although the accurate and detailed, fundamental role of the microglial cells continues to be discovered and explained, there is a consensus among many researchers that primed microglia are associated with the inflammatory response of the CNS in AD. It has also been determined that neuroinflammation caused by microglial priming is mainly associated with aging, systemic inflammation, gene regulation, and blood-brain barrier impairment. The purpose of the article below is to discuss how microglial priming and neuroinflammation in Alzheimer’s disease can be caused due to a variety of risk factors.  

 

Aging

 

Aging is considered to be one of the main risk factors for AD and it is generally followed by chronic, systemic up-regulation of pro-inflammatory factors and a considerable decrease in an anti-inflammatory response. This change from homeostasis to an inflammatory state occurs through age-related elements which cause an imbalance between anti-inflammatory and pro-inflammatory systems. Microglia is primed into an activated state which can increase the consistent neuroinflammation and inflammatory reactivity in the aged human brain. Research studies have demonstrated that microglia in the brain of rodents developed an activated phenotype during aging characterized by the increased expression of CD11b, CD11c, and CD68.  

 

Systemic Inflammation

 

Recent research studies have determined that the neuroinflammation from primed microglial cells can also cause the pathogenesis of AD. Continuous activation of microglia can promote the synthesis and secretion of pro-inflammatory cytokines and trigger a pro-inflammatory response, ultimately causing neuronal damage. Neuroinflammation is an early symptom in the progression of AD. The microglia can have a tremendous effect on the inflammation of the human brain.  

 

The inflammation and health issues of the CNS can be associated with systemic inflammation through molecular pathways. One research study demonstrated that ROS development of primed microglia decreases the levels of intracellular glutathione and increases nitric oxide in NADPH oxidase subunit NOX2. Moreover, researchers demonstrated that these simultaneously occurring processes ultimately cause the development of more neurotoxic peroxynitrite. This is demonstrated in rodents with peripheral LPS or proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6, IL-33.  

 

The outcome measures of numerous research studies have demonstrated that systemic inflammation can cause microglial activation. The results of the research studies emphasize the variability of the inflammatory response in the human brain associated with AD and the underlying health issues associated with systemic inflammation and neuroinflammation, as shown in Table 1. MAPK (mitogen-activated protein kinase) signaling pathways regulate mechanisms of the eukaryotic cell and microglial MAPK can also cause an inflammatory response to the aged brain with AD. Furthermore, chronic or continuous systemic inflammation causes neuroinflammation, resulting in the onset and accelerating the progression of AD.  

 

Table 1 Effects of Inflammatory Cytokines in AD | El Paso, TX Chiropractor  

Genetic Regulation

 

In the aging human brain, gene regulation has ultimately been associated with an innate immune response. Recent preclinical, bioinformatics, and genetic data have demonstrated that the activation of the brain immune system is associated with the pathology of AD and causes the pathogenesis of this neurological disease. Genome-wide association studies (GWAS), functional genomics, and even proteomic evaluations of cerebrospinal fluid (CSF) and blood have demonstrated that dysfunctional immune pathways from genic mutation are risk factors in LOAD, which is the vast majority of AD.  

 

GWAS have become a fundamental tool in the screening of genes as well as demonstrating several new risk genes associated with AD. Apolipoprotein E (APOE) ε4allele is one of the most considerable and well-known risk genes for sporadic AD and this mutation ultimately increases the risk of neurological disease onset by 15 times in homozygous carriers and by three times in heterozygous carriers. Further research studies have demonstrated how microglial cell function can be affected through a variety of rare mutations which have demonstrated to have an increased risk factor of Alzheimer’s disease.  

 

An extracellular domain mutation of the TREM2 gene has also demonstrated an almost identical extent with APOEε4 in increasing the risk factor of AD. TREM2 is increasingly demonstrated on the surface of microglia and mediates phagocytosis as well as the removal of neuronal debris. Additionally, several other genes, such as PICALM, Bin1, CLU, CR1, MS4A, and CD33 have been demonstrated as risk genes for AD. Most of the risk mutation genes are expressed by microglial cells.  

 

Blood-Brain Barrier (BBB) Impairment

 

The blood-brain barrier (BBB) is a specialized barrier commonly developed between the blood and the brain by tight liner sheets consisting of specific endothelial cells and tight junctions or structures which connects a variety of cells together. The CNS is fundamental for the human body, and the BBB is fundamental for the CNS. The BBB and the blood-nerve barrier develop a defense system to control the communications of cells and soluble factors between blood and neural tissue where it plays a considerable role in maintaining and regulating the homeostasis of the CNS and peripheral nervous system.  

 

With development, continuous inflammation can also cause damage to the BBB. This damage can ultimately cause loss of hypersensitive neurons, neuroinflammatory regions, and focal white matter impairment following the damage. The compromised BBB also allows more leukocytes to enter into the CNS where an immune response can be aggravated by brain microglia under the condition of peripheral inflammation. These processes may ultimately be under the control of chemokine and cytokine signaling which can also have an effect on brain microglial cells as well as other health issues in AD.  

 

By way of instance, it has been determined that TNF-α, IL-17A, and IL-1β can reduce the tight junctions and eliminate the BBB. Loss of BBB integrity and abnormal expression of tight junctions are associated with neuroinflammation. Several research studies also demonstrated in an animal model of AD that the vulnerability of BBB to inflammation increases. Current evidence has also demonstrated that the BBB integrity is fundamental while further evidence of the BBB may demonstrate a new treatment approach for AD associated with microglial priming as shown in Figure 2 below.  

 

Microglial Priming and AD | El Paso, TX Chiropractor  

Conclusion

 

Microglia play a fundamental role in maintaining and regulating the homeostasis of the CNS’s micro-environment. If the balance of the homeostasis of the human brain is interrupted, the microglial cells can be activated to restore the balance in the CNS by defending against the stimulation and protecting the structure and function of the brain. However, chronic and continuous stimulation can trigger microglia into a state known as microglial priming, which is more sensitive to potentially minor stimulation, causing a variety of health issues, such as central sensitization, chronic pain, and fibromyalgia.  

 

Microglial priming mainly causes the boost of Aβ, tau protein as well as neuroinflammation and reduces neurotrophic factors which can cause the loss of healthy brain cells or neurons as well as the development of neuritic plaques and neurofibrillary tangles which are associated with Alzheimer’s disease. Although this “double-edged sword” plays a fundamental role, it can increase the progression of abnormal protein development and aggravate neuronal loss and dysfunction. However, research studies have ultimately demonstrated that aging can cause the progression of AD and there’s not much we can do about it.  

 

El Paso Chiropractor Dr. Alex Jimenez

Microglial cells play a fundamental role as the protectors of the brain and they ultimately help maintain as well as regulate the homeostasis of the CNS microenvironment. However, continuous stimulation can cause the microglia to trigger and activate at a much stronger state which is known as microglial priming. Once the microglial cells go into protective mode, however, primed microglia can become much more sensitive to even minor stimulation and they have a much stronger possibility of reacting towards normal cells. Microglial priming has been associated with neuroinflammation and Alzheimer’s disease (AD) as well as central sensitization and fibromyalgia. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

 


 

Neuropathy Treatment with LLLT

 

 


 

AD is one of the most common types of dementia among older adults. However, the pathogenesis of AD is misunderstood and there is no definitive treatment for the neurological disease. Research studies have ultimately demonstrated that the activation and priming of microglial cells may contribute to the pathogenesis of AD. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .  

 

Curated by Dr. Alex Jimenez  

 


 

Additional Topic Discussion: Chronic Pain

 

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.

 

 


 

Neural Zoomer Plus for Neurological Disease

 

Neural Zoomer Plus | El Paso, TX Chiropractor

 

Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual’s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.  

 

Formulas for Methylation Support

Xymogen Formulas - El Paso, TX

 

XYMOGEN’s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

 

Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

 

Please call our office in order for us to assign a doctor consultation for immediate access.

 

If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

xymogen el paso, tx

 

For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download  

 

* All of the above XYMOGEN policies remain strictly in force.

 


 

 

Trauma Specialist Testimonies and Case Studies

Why Patients Choose Accidents Specialist to Treat Injuries
By Dr. Alexander Jimenez
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  1. 1 Chiropractic Care on Whiplash | El Paso, Tx Chiropractic Care on Whiplash | El Paso, Tx 02:15
  2. 2 Car accident Injury Rehabilitation | El Paso, Tx Car accident Injury Rehabilitation | El Paso, Tx 02:19
  3. 3 *CAR ACCIDENTS* Chiropractor | El Paso, Tx (2019) *CAR ACCIDENTS* Chiropractor | El Paso, Tx (2019) 02:35
  4. 4 Recommended El Paso, TX Chiropractor Recommended El Paso, TX Chiropractor 03:43
  5. 5 Severe Back Pain Chiropractic Treatment El Paso, TX Severe Back Pain Chiropractic Treatment El Paso, TX 04:09
  6. 6 *CHRONIC* Pain Chiropractic Care | El Paso, Tx (2019) *CHRONIC* Pain Chiropractic Care | El Paso, Tx (2019) 02:38
  7. 7 *Car Accident Injury* Chiropractic Solution  |  El Paso, TX (2019) *Car Accident Injury* Chiropractic Solution | El Paso, TX (2019) 02:25
  8. 8 Chronic Pain Chiropractor | El Paso, Tx (2019) Chronic Pain Chiropractor | El Paso, Tx (2019) 02:07
  9. 9 Chiropractic Help on Car Accidents | El Paso, Tx Chiropractic Help on Car Accidents | El Paso, Tx 02:27
  10. 10 *Car Accident Injuries* Treatment  |  El Paso, TX (2019) *Car Accident Injuries* Treatment | El Paso, TX (2019) 02:18
  11. 11 Why Chiropractor for Auto Injuries? | El Paso, Tx Why Chiropractor for Auto Injuries? | El Paso, Tx 02:30
  12. 12 *Neck* Pain Chiropractic Care | El Paso, Tx (2019) *Neck* Pain Chiropractic Care | El Paso, Tx (2019) 02:59
  13. 13 Personal Injury Chiropractic Care | El Paso, Tx (2019) Personal Injury Chiropractic Care | El Paso, Tx (2019) 02:16
  14. 14 Most Effective Chiropractor | El Paso, Tx (2019) Most Effective Chiropractor | El Paso, Tx (2019) 03:16
  15. 15 Personal Injury Lawyers & Chiropractors | El Paso, Tx Personal Injury Lawyers & Chiropractors | El Paso, Tx 02:47
  16. 16 Top Chiropractor Near Me | El Paso, Tx (Best) Top Chiropractor Near Me | El Paso, Tx (Best) 02:29
  17. 17 Chronic Body Pain Recovery | El Paso, Tx Chronic Body Pain Recovery | El Paso, Tx 01:57
  18. 18 Chiropractic Pain Relief | El Paso, Tx Chiropractic Pain Relief | El Paso, Tx 01:56
  19. 19 Quiropractico Recomendado | El Paso, Tx Quiropractico Recomendado | El Paso, Tx 02:11
  20. 20 Most Recommended Chiropractor El Paso, Tx Most Recommended Chiropractor El Paso, Tx 02:04
  21. 21 El Paso, TX Shoulder Pain Chiropractic Treatment El Paso, TX Shoulder Pain Chiropractic Treatment 02:52
  22. 22 El Paso, TX Lower Back Pain Chiropractor Treatment El Paso, TX Lower Back Pain Chiropractor Treatment 05:51
  23. 23 El Paso, TX Chiropractic Treatment for Car Accidents El Paso, TX Chiropractic Treatment for Car Accidents 02:37
  24. 24 El Paso, TX 18 Wheeler Accident Chiropractic Treatment El Paso, TX 18 Wheeler Accident Chiropractic Treatment 02:23
  25. 25 Chiropractic Neck Pain Treatment El Paso, TX Chiropractic Neck Pain Treatment El Paso, TX 02:14
  26. 26 El Paso, TX Chiropractor 79936 El Paso, TX Chiropractor 79936 02:00
  27. 27 Sciatica Pain Treatment in El Paso, TX Chiropractic Care Sciatica Pain Treatment in El Paso, TX Chiropractic Care 01:56
  28. 28 El Paso, TX Chiropractic Care For Auto Accidents El Paso, TX Chiropractic Care For Auto Accidents 03:28
  29. 29 El Paso, TX Chiropractic Care Neck Pain Treatment El Paso, TX Chiropractic Care Neck Pain Treatment 04:47
  30. 30 El Paso, TX Chiropractor Auto Accident Injuries El Paso, TX Chiropractor Auto Accident Injuries 07:00
  31. 31 El Paso, TX Chiropractor New Patient Intake Form El Paso, TX Chiropractor New Patient Intake Form 02:05
  32. 32 Whiplash Chiropractic Massage Therapy El Paso, TX Whiplash Chiropractic Massage Therapy El Paso, TX 01:55
  33. 33 El Paso, TX Cervical Pain Treatment Chiropractic Care El Paso, TX Cervical Pain Treatment Chiropractic Care 05:08
  34. 34 18 Wheeler Accident Pain Treatment Chiropractor El Paso, TX 18 Wheeler Accident Pain Treatment Chiropractor El Paso, TX 02:23
  35. 35 Shoulder Pain Treatment El Paso, TX Chiropractor Shoulder Pain Treatment El Paso, TX Chiropractor 02:49
  36. 36 Back Pain Management El Paso, TX Chiropractor Back Pain Management El Paso, TX Chiropractor 05:51
  37. 37 Car Accident Injury Treatment El Paso, TX Chiropractor Car Accident Injury Treatment El Paso, TX Chiropractor 02:36
  38. 38 Auto Accident Injury Treatment El Paso, TX Auto Accident Injury Treatment El Paso, TX 02:15
  39. 39 Neck Pain Treatment El Paso, TX Chiropractor Neck Pain Treatment El Paso, TX Chiropractor 02:15
  40. 40 Slip And Fall Injury Treatment El Paso, TX Chiropractor Slip And Fall Injury Treatment El Paso, TX Chiropractor 01:55
  41. 41 *CHIROPRACTOR* The Most Recommended | El Paso, Tx (2019) *CHIROPRACTOR* The Most Recommended | El Paso, Tx (2019) 02:19
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