El Paso's Chiropractic Team
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Intestinal Permeability and Disease

Increased intestinal permeability is the gateway to autoimmune diseases. It has become well-known that intestinal permeability is the third element leading to autoimmune pathogenesis along with genetic factors and environmental triggers.

Environmental triggers that lead to autoimmune disease.
Infection
Toxic molecules
Allergenic foods (or diet, for example, wheat.)

Nevertheless, these factors interplay with the neuroendocrine network, gut-associated lymphoid tissue, intestinal barrier, and eventually, the integrity of tight junctions between the epithelial cells. Eventually, the correct function of these factors will control and promote a balanced immune response.

Did you know most common chronic diseases are associated with an autoimmune response? Chronic inflammatory diseases like diabetes mellitus type II, inflammatory bowel disease, multiple sclerosis, gestational diabetes, and hyperlipidemia, to name a few. Therefore, if we are going to deal with autoimmune diseases, then why not treat the predecessor of this mechanism? Treat the gut, improve intestinal permeability = healthy patient.

Why treat the gut if the patient came in with a metabolic disease? The intestinal barrier has a crucial function; it regulates macromolecules’ traffic from food to protect the host. Inflammation is the first stage of every disease, and increased intestinal permeability is liked to higher measurements of inflammation markers.

What happens in the gut never stays in the gut…

Learn more on how inflammation, gut permeability, and an exaggerated immune response can lead to disease.

There are 2 possible ways that macromolecules are entering our bloodstream:

1.- Paracellular entry: between out epithelial cells, we have something called tight junctions. Actually, the name says it all; the tight junctions are involved in holding together our epithelial cells with the help of proteins like claudin and occludin. These proteins are a band-like structure that allows a narrow space between each cell and controls molecules’ passage.

Hence, when an environmental injury breaks these bands, large molecules pass between the epithelial cells and enter the submucosa.

2.- Transcellular entry: This happens when the antigen passes through the epithelial cell, rupturing it, and then enters the submucosa.

How gut permeability leads to autoimmunity and disease:
1.     Environmental triggers.
2.     Breakdown in oral tolerance.
3.     Change in gut microbiota.
4.     Enhanced gut permeability.
5.     Large macromolecules pass through the compromised gut barrier.
6.     Immune reactivity.
7.     Autoimmunity.

 

Newest breakthrough: Zonulin

Did you know that gliadin, a protein found in gluten-containing grains, upregulates zonulin?

What is zonulin? Is a newly recognized intestinal peptide that is associated with tight junction regulation. It is found to be responsible for the gut permeability found in celiac disease patients. In recent studies, zonulin has been used as a marker for intestinal permeability.

Zonulin, along with proinflammatory molecules like TNF-a and INF-y, promote the upregulation of lipid draft, which consists of a pathogen carried by lipid and crossing the intestinal barrier in a transcellular way. Nevertheless, new studies have shown that paracellular entry always precedes the transcellular pathway. This means that whenever our inflammation markers increase and zonulin signaling is activated, the potential of an autoimmune response grows higher. Also, research shows that zonulin can be upregulated regardless of the genetic expression of autoimmunity.

Paracellular entry always precedes the transcellular pathway.

We have to consider the size of the molecule that is crossing the epithelial barrier. For example, if a patient has good intestinal permeability, only small molecules will cross the epithelial barrier. Smaller molecules do not cause an immune response. On the other hand, when microvilli get compromised, tight junctions are open, and actin filaments are diminished. Large molecules like gluten peptides and lipopolysaccharides can easily enter the submucosa, inevitably cause an immune reaction.

 

Gut permeability:
1.     Antigens delivered through an easy access permeable lining.
2.     Activation on the innate immune response.
§  IFN-y
§  TNF-a
§  Il-1B
3.     Antibody production that affects barrier permeability.
4.     Transcellular and paracellular translocation via intestinal permeability.
5.     Dysregulated immune response.
6.     Autoimmune mechanism initiated.

In conclusion, we must treat intestinal permeability. Despite the patient’s genetic predisposition, the environmental triggers and gut permeability are the main factors that we can change to control an exacerbated immune response. Also, autoimmune diseases can affect every tissue in our body, indicating that what happens in the gut spreads through our body.

Drago, Sandro, et al. “Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines.” Scandinavian journal of gastroenterology 41.4 (2006): 408-419.

Fasano, Alessio. “All disease begins in the (leaky) gut: Role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases.” F1000Research 9 (2020).

Vibrant Educational Series. 2018. Intestinal Permeability. [Video] www.youtube.com/watch?v=VYIj5PE_F0o

Additional Useful Links:

Set Appointments 24/7:
Book Online Appointment: bit.ly/Book-Online-Appointment

Take Your Functional Wellness Assessment Today:
Online Functional Medicine Assessment: bit.ly/functionmed

Post Disclaimers

Professional Scope of Practice *

The information herein on "Intestinal Permeability and Disease" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*
Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card

Comments are closed.

Again, I Welcome You.

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training, and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, and young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the city’s premier doctors, therapists, and trainers to provide high-level competitive athletes the possibility to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, unwanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING!

Welcome & God Bless

EL PASO LOCATIONS

East Side: Main Clinic*
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677

Central: Rehabilitation Center
6440 Gateway East, Ste B
Phone: 915-850-0900

North East Rehabilitation & Fitness Center
7100 Airport Blvd, Ste. C
Phone: 915-412-6677

Dr. Alex Jimenez DC, MSACP, CIFM, ATN, IFMCP
My Digital Business Card

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone
: (915) 412-6677
Email: Send Email
Webwww.DrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
EmailSend Email
Webwww.ElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
EmailSend Email
Webwww.ChiropracticScientist.com

Push As Rx Crossfit & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone
: (915) 412-6677
EmailSend Email
Webwww.PushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone
: (915) 412-6677
EmailSend Email
Webwww.PushAsRx.com

Just Play 24/7

Address: 7100 Airport Blvd
El Paso, TX 79906
Phone
: (915) 412-6677
EmailSend Email
Webwww.JustPlay.us

Your New Rehabilitation & Fitness Center*

(Come Join Us Today)

Rated Top El Paso Doctor & Specialist by RateMD* | Years 2012 thru 2022

Top Rated Chiropractor El Paso

EVENTS REGISTRATION: Live Events & Webinars*

(Come Join Us & Register Today)

No Events Found

Call (915) 850-0900 Today!

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form: bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment: bit.ly/functionmed
  1. General Disclaimer *

    The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, or licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified healthcare professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

    We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

    Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

    email: coach@elpasofunctionalmedicine.com

    phone: 915-850-0900

    Licensed in: Texas & New Mexico*

    Dr. Alex Jimenez DC, MSACP, CIFM, IFMCP, ATN, CCST
    My Digital Business Card

Post Disclaimers

Professional Scope of Practice *

The information herein on "Intestinal Permeability and Disease" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*
Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card