Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Blood Glucose and Hintonia Latiflora

Hintonia Latiflora (family Rubiaceae) is a bark of a Central American plant. In Mexico, Hintonia Latiflora is commonly known as “copalchis” and is extensively applied by patients with non-insulin-dependent diabetes mellitus. The blood glucose-lowering effects of Hintonia Latiflora have recently gained the scientific community’s attention and applied in several research settings.

 

In recent studies, the isolation of several cucurbitacins and 4-phenylcoumarins were identified. The antimicrobial properties of these compounds are extensively studied, as well. Nevertheless, the antidiabetic effect of H. Latiflora has been reported since 1989 in Mexico, followed by studies made in Germany, France, and Italy.

 

In 2000, oral administration of H. latiflora in STZ-diabetic mice resulted in decreased levels of blood glucose. However, the natural active compounds were not identified in this study. Furthermore, new research has shown that the fun

Hintonia Latiflora (family Rubiaceae) is a bark of a Central American plant. In Mexico, Hintonia Latiflora is commonly known as “copalchis” and is extensively applied by patients with non-insulin-dependent diabetes mellitus. The blood glucose-lowering effects of Hintonia Latiflora have recently gained the scientific community’s attention and applied in several research settings.

 

In recent studies, the isolation of several cucurbitacins and 4-phenylcoumarins were identified. The antimicrobial properties of these compounds are extensively studied, as well. Nevertheless, the antidiabetic effect of H. Latiflora has been reported since 1989 in Mexico, followed by studies made in Germany, France, and Italy.

 

In 2000, oral administration of H. latiflora in STZ-diabetic mice resulted in decreased levels of blood glucose. However, the natural active compounds were not identified in this study. Furthermore, new research has shown that the functional compound of Mexican “copalchis” were 4-phenylcoumarin glycosides and cucurbitacins, and compounds 2 and 6.

 

H. Latiflora application:
Antihyperglycemic effect.
Improves plasma insulin levels.
Modules hepatic glycogen.

 

The chemical composition of H. Latiflora had to be identified by chromatographic fractionation. This study identified 8 compounds:

Latiflora composition

 

1)    25-O-acetyl-3-O-b-D-gluco- pyranosyl-23,24-dihydrocucurbitacin F
2)    3-O-b-D-glucopyr- anosyl-23,24-dihydrocucurbitacin F
3)    5-O-b-D-glucopyranosyl-7-methoxy-3’,4’-dihydroxy-4-phenylcoumarin
4)    5- O-b-D-galactopyranosyl-7-methoxy-3’ ,4’ -dihydroxy-4-phenylcoumarin
5)    5-O-b-D-glucopyranosyl-7,3’,4’-trihydroxy-4-phenylcoumarin
6)    5-O-[b-D-apiofuranosyl- (1 -6)-b-D-glucopyranosyl]-7-methoxy-3’,4’-dihydroxy-4- phenylcoumarin
7)    5-O-[b-D-xylopyranosyl-(1-6)-b-D- glucopyranosyl]-7-methoxy-3’ ,4’ -dihydroxy-4-phenylcoumarin
8)    alkaloid desoxycordifolinic acid
Latiflora research

 

Conducted research with H. Latiflora, an STZ- induced diabetic mice, has been done using similar extracts like E. caribaeum. Furthermore, the objective of intervening STZ- induced diabetic mice with this extract mixture was to observe the long-term antidiabetic effects. Furthermore, the daily oral administration results of 50mg/kg of H. latiflora, 2-6 and 8 (15mg/kg) twice a day for 30 days. This intervention resulted in an improvement in glucose levels.

 

Human studies

 

Another long-term study lasting 33 months resulted in the maintenance or lowering of HbA1c to 7%. Indeed, these results showed after six months of consumption.

However, new studies have applied H. Latiflora as a capsule with dry extract. They choose to combine this extract with vitamin C, vitamin E, zinc, chromium, and vitamin b compound. Consequently, the results of these studies confirmed positive effects on the regulation of blood glucose balance.

It is important to mention that H. Latiflora supplementation has reported excellent tolerance. Besides, to lowering blood glucose, liver function and lipid were positively affected. By reading and reporting these studies, they all conclude that the supplementation of H. latiflora, combined with other extracts or vitamins and trace minerals, has a positive effect on blood glucose.

 

Despite confirming the antidiabetic effects of H. Latiflora, some studies were conducted to reduce the hypoglycemic effect of antidiabetic oral medication reported in large studies like ACCORD and ADVANCE. Both large studies report increased long term mortality associated with tight blood glucose control and aggressive lowering of HbA1c, caused by medication. Nevertheless, H. Latiflora has only shown positive effects in patients with mild and moderate type 2 diabetes.

 

In conclusion, human studies performed with H. Latiflora have shown that this Central American bark has positive blood glucose effects. Consequently, it is strongly advised to use this supplement with patients with mild to moderate T2DM.

 

 

References

 

Korecova, Marta, and Marie Hladikova. “Treatment of mild and moderate type-2 diabetes: an open, prospective trial with Hintonia latiflora extract.” European journal of medical research 19.1 (2014): 1-6.

 

Guerrero-Analco, José, et al. “Antidiabetic properties of selected Mexican copalchis of the Rubiaceae family.” Phytochemistry 68.15 (2007): 2087-2095.

 

 

 

Additional Online Links & Resources (Available 24/7)



Online Appointments or Consultations:  https://bit.ly/Book-Online-Appointment

 

Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History

 

Online Functional Medicine Assessment: https://bit.ly/functionmed

 

Dr. Alex Jimenez’s Blog Post

 

Disclaimer

 

Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us 915-850-0900.  The provider(s) Licensed in Texas& New Mexico

 

 

 

Again, I Welcome You 👊🏻.

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises and advanced agility treatment options. We have teamed up with the cities premier doctors, therapist and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, un-wanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING! 🍎

Welcome & God Bless

EL PASO LOCATIONS

Central:
6440 Gateway East, Ste B
Phone: 915-850-0900

East Side:
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone
: (915) 412-6677
EmailSend Email
Webwww.DrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
EmailSend Email
Webwww.ElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
EmailSend Email
Webwww.ChiropracticScientist.com

Push As Rx Crossfit & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone
: (915) 412-6677
EmailSend Email
Webwww.PushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone
: (915) 412-6677
EmailSend Email
Webwww.PushAsRx.com

🔴 Rated Top El Paso Doctor & Specialist by ✔️ RateMD* | Years 2014,2015,2016,2017,2018,2019

Top Rated Chiropractor El Paso

EVENTS REGISTRATION: Live Events & Webinars* ❗️

(Come Join Us & Register Today)

Call (915) 850-0900 Today!

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  https://bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment: https://bit.ly/functionmed
  1. Disclaimer

    The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 Read More…

    Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG*

    email: coach@elpasofunctionalmedicine.com
    phone: 915-850-0900
    Licensed in Texas & New Mexico

eventbrite® WEBINARS
PAIN HISTORY 24•7
Book Personal Injury Appointment
BOOK ONLINE 24•7