Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Traumatic Brain Injury and Neurodegenerative Diseases Part 1

Traumatic brain injury (TBI) is one of the most common causes of disability and death in people. About 1.6 million individuals suffer traumatic brain injuries in the United States every year. TBI can cause a process of injury which may ultimately cause a variety of neurodegenerative diseases and other health issues. Many of the neurodegenerative diseases following TBI include health issues such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS).  

 

The mechanisms underlying the pathogenesis which result in these type of neurodegenerative diseases, however, are still completely misunderstood. Where many of the health issues following TBI have a high incidence, there are currently only several treatment approaches which can help prevent the pathological development of chronic neurological diseases.  

 

A better understanding of the mechanisms underlying TBI and neurodegenerative diseases is ultimately fundamental to determine the possible connection between these health issues to allow safe and effective diagnosis and treatment. In part 1 of the following article, we will discuss the pathological mechanisms of traumatic brain injury (TBI) and how it’s associated with the development of a variety of neurological diseases and other health issues, including Alzheimer’s disease (AD).  

 

Pathological Mechanisms of Traumatic Brain Injury

 

In most instances, TBI is caused by a physical blow to the head during traumatic events, such as falls, automobile accidents, or sports-related accidents, although TBI may also be aggravated by exposure to explosive blasts. TBI can be characterized as mild, moderate, or severe according to the symptoms, such as the length of loss of consciousness and post-traumatic amnesia. Mild TBI (mTBI) is prevalent in the majority of cases, however, it may be difficult to diagnose. This difficulty in diagnosis can be a serious concern as a result of severe consequences like instant impact syndrome or other health issues.  

 

Damage to the nervous tissue can be characterized as the main injury which happens as a direct effect of a physical blow and secondary injury which happens due to pathophysiological processes subsequent to the traumatic event. The injury process occurs from the rapid acceleration-deceleration of the brain which is believed to harm the brain by causing sheer force within tissue resulting in impact and axonal injury with the cranial wall. These injuries can be contralateral or ipsilateral to the physical blow. In more severe instances, the injury may cause intracranial hypertension and intracranial hemorrhage. This increase in pressure not only damages brain tissue but it also causes potential injury and cerebral hypoperfusion.  

 

Secondary injury in TBI generally happens several days, weeks, and even months following the traumatic circumstance because of the biochemical changes which occur in the nervous tissue. This harm is often mediated by free radicals and reactive oxygen species (ROS) which develop from ischemia-reperfusion damage, glutamatergic excitotoxicity, or neuroinflammation. After the injury, axonal damage from the sheer force of injury can affect membrane balance. Moreover, uptake of calcium through either membrane disruption or activation of the NMDA and the AMPA receptors by glutamate could ultimately cause mitochondrial dysfunction as well as the overproduction of free radicals and the activation of apoptotic caspase signaling. Following inflammatory processes associated with TBI, such as the activation of microglial cells, can cause oxidative stress through the effects of inflammatory cytokines. These radicals can also cause cellular damage through lipid peroxidation and protein modifications which can overwhelm endogenous antioxidant systems. The secondary products of free radical-mediated lipid peroxidation, such as reactive carbonyl species, can also be electrophilic and can further propagate oxidative damage to biomacromolecules, which can be associated with various neurological diseases.  

 

Clinical and preclinical research studies have demonstrated the presence of oxidative stress and its byproducts following TBI with both serological and histological methods and techniques. In animal research studies, these products have been demonstrated to continue over a recurrent injury and it may increase following a single traumatic event. Spectroscopic evaluations suggest that the endogenous antioxidants glutathione and ascorbic acid may decrease for 3 to 14 days following the injury. Furthermore, the increase of F2-isoprostane, a lipid peroxidation byproduct, was demonstrated in the cerebrospinal fluid of severe TBI patients with increased levels at 1 day following the injury, however, this was primarily an assessment of alternative treatment and didn’t establish a contrast with healthy controls. Lipid peroxidation products like 4-hydroxynoneal were also found to be elevated in the serum of acute TBI patients needing treatment. Although chronic oxidative stress has not currently been detected following single mild injuries in people, it seems possible that oxidative stress and its associated processes may aggravate or prolong post-concussive symptoms. Given the involvement of oxidative stress in excitotoxicity and reperfusion injury, it’s possible that oxidative stress plays a role in cerebral injury after TBI.  

 

The pathological mechanisms of secondary TBI are particularly interesting due to the ability to prolong cellular injury beyond the initial traumatic event. Some of these characteristic modifications, such as oxidative stress and excitotoxicity, have also been demonstrated in the pathophysiology of neurodegenerative diseases and other health issues which also suggests a possible pathological mechanistic connection between TBI and neurological diseases. Further research studies of the pathological mechanisms in cerebral diseases and TBI may help determine the factors for neurodegenerative diseases.  

 

Conclusion

 

Despite the prevalence of TBI the significant neurological sequelae associated with such injuries, diagnosis and treatment of TBI remains greatly misunderstood. In addition, the causing factors connected to TBI and neurodegenerative diseases, such as AD, PD, ALS, and CTE, have not been fully determined. Several processes, including oxidative stress and neuroinflammation, have also been found to be common between secondary TBI and several neurodegenerative diseases. In particular, oxidative stress appears to be the key mechanism connecting neuroinflammation and glutamatergic excitotoxicity in both TBI and neurological diseases. It is possible that the oxidative cascade caused by TBI ultimately causes and results in the characteristic pathologies of neurodegenerative diseases through oxidation or carbonylation of essential proteins.  

 

Due to the high prevalence of TBI and neurodegenerative diseases, the development of new safe and effective treatment approaches for TBI is fundamental. Given the essential role that oxidative stress plays in connecting secondary injury and neurodegeneration, detection of ROS and key byproducts could serve as a method or technique for the diagnosis and treatment of potential cellular damage. Finally, these reactive species may serve as a viable therapeutic target for reducing long-term neurodegenerative disease risk following TBI, helping to reduce the disability and death as well as improve the quality of life of individuals in the United States that suffer from traumatic brain injury (TBI) and other health issues.  

 

El Paso Chiropractor Dr. Alex Jimenez

Traumatic brain injury is among one of the most prevalent causes of disability and death among the general population in the United States. According to a variety of research studies, mild, moderate, and severe traumatic brain injury has been associated with neurodegenerative diseases, such as Alzheimer’s disease, as well as a variety of other neurological diseases and health issues. It is fundamental to understand the pathophysiological mechanisms of traumatic brain injury while further research studies are still required to determine the association between TBI and neurodegenerative diseases. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

 


 

Neuropathy Treatment with LLLT

 

 


 

Traumatic brain injury (TBI) is one of the most common causes of disability and death in people. About 1.6 million individuals suffer traumatic brain injuries in the United States every year. TBI can cause a process of injury which may cause a variety of neurodegenerative diseases and health issues, such as Alzheimer’s disease (AD). The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .  

 

Curated by Dr. Alex Jimenez  

 


 

Additional Topic Discussion: Chronic Pain

 

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.

 

 


 

Neural Zoomer Plus for Neurological Disease

  Neural Zoomer Plus | El Paso, TX Chiropractor  

Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual’s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.  

 

Formulas for Methylation Support

Xymogen Formulas - El Paso, TX

 

XYMOGEN’s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

 

Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

 

Please call our office in order for us to assign a doctor consultation for immediate access.

 

If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

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For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download  

 

* All of the above XYMOGEN policies remain strictly in force.

 


 

 

Trauma Specialist Testimonies and Case Studies

Why Patients Choose Accidents Specialist to Treat Injuries
By Dr. Alexander Jimenez
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  1. 1 Chiropractic Care on Whiplash | El Paso, Tx Chiropractic Care on Whiplash | El Paso, Tx 02:15
  2. 2 Car accident Injury Rehabilitation | El Paso, Tx Car accident Injury Rehabilitation | El Paso, Tx 02:19
  3. 3 *CAR ACCIDENTS* Chiropractor | El Paso, Tx (2019) *CAR ACCIDENTS* Chiropractor | El Paso, Tx (2019) 02:35
  4. 4 Recommended El Paso, TX Chiropractor Recommended El Paso, TX Chiropractor 03:43
  5. 5 Severe Back Pain Chiropractic Treatment El Paso, TX Severe Back Pain Chiropractic Treatment El Paso, TX 04:09
  6. 6 *CHRONIC* Pain Chiropractic Care | El Paso, Tx (2019) *CHRONIC* Pain Chiropractic Care | El Paso, Tx (2019) 02:38
  7. 7 *Car Accident Injury* Chiropractic Solution  |  El Paso, TX (2019) *Car Accident Injury* Chiropractic Solution | El Paso, TX (2019) 02:25
  8. 8 Chronic Pain Chiropractor | El Paso, Tx (2019) Chronic Pain Chiropractor | El Paso, Tx (2019) 02:07
  9. 9 Chiropractic Help on Car Accidents | El Paso, Tx Chiropractic Help on Car Accidents | El Paso, Tx 02:27
  10. 10 *Car Accident Injuries* Treatment  |  El Paso, TX (2019) *Car Accident Injuries* Treatment | El Paso, TX (2019) 02:18
  11. 11 Why Chiropractor for Auto Injuries? | El Paso, Tx Why Chiropractor for Auto Injuries? | El Paso, Tx 02:30
  12. 12 *Neck* Pain Chiropractic Care | El Paso, Tx (2019) *Neck* Pain Chiropractic Care | El Paso, Tx (2019) 02:59
  13. 13 Personal Injury Chiropractic Care | El Paso, Tx (2019) Personal Injury Chiropractic Care | El Paso, Tx (2019) 02:16
  14. 14 Most Effective Chiropractor | El Paso, Tx (2019) Most Effective Chiropractor | El Paso, Tx (2019) 03:16
  15. 15 Personal Injury Lawyers & Chiropractors | El Paso, Tx Personal Injury Lawyers & Chiropractors | El Paso, Tx 02:47
  16. 16 Top Chiropractor Near Me | El Paso, Tx (Best) Top Chiropractor Near Me | El Paso, Tx (Best) 02:29
  17. 17 Chronic Body Pain Recovery | El Paso, Tx Chronic Body Pain Recovery | El Paso, Tx 01:57
  18. 18 Chiropractic Pain Relief | El Paso, Tx Chiropractic Pain Relief | El Paso, Tx 01:56
  19. 19 Quiropractico Recomendado | El Paso, Tx Quiropractico Recomendado | El Paso, Tx 02:11
  20. 20 Most Recommended Chiropractor El Paso, Tx Most Recommended Chiropractor El Paso, Tx 02:04
  21. 21 El Paso, TX Shoulder Pain Chiropractic Treatment El Paso, TX Shoulder Pain Chiropractic Treatment 02:52
  22. 22 El Paso, TX Lower Back Pain Chiropractor Treatment El Paso, TX Lower Back Pain Chiropractor Treatment 05:51
  23. 23 El Paso, TX Chiropractic Treatment for Car Accidents El Paso, TX Chiropractic Treatment for Car Accidents 02:37
  24. 24 El Paso, TX 18 Wheeler Accident Chiropractic Treatment El Paso, TX 18 Wheeler Accident Chiropractic Treatment 02:23
  25. 25 Chiropractic Neck Pain Treatment El Paso, TX Chiropractic Neck Pain Treatment El Paso, TX 02:14
  26. 26 El Paso, TX Chiropractor 79936 El Paso, TX Chiropractor 79936 02:00
  27. 27 Sciatica Pain Treatment in El Paso, TX Chiropractic Care Sciatica Pain Treatment in El Paso, TX Chiropractic Care 01:56
  28. 28 El Paso, TX Chiropractic Care For Auto Accidents El Paso, TX Chiropractic Care For Auto Accidents 03:28
  29. 29 El Paso, TX Chiropractic Care Neck Pain Treatment El Paso, TX Chiropractic Care Neck Pain Treatment 04:47
  30. 30 El Paso, TX Chiropractor Auto Accident Injuries El Paso, TX Chiropractor Auto Accident Injuries 07:00
  31. 31 El Paso, TX Chiropractor New Patient Intake Form El Paso, TX Chiropractor New Patient Intake Form 02:05
  32. 32 Whiplash Chiropractic Massage Therapy El Paso, TX Whiplash Chiropractic Massage Therapy El Paso, TX 01:55
  33. 33 El Paso, TX Cervical Pain Treatment Chiropractic Care El Paso, TX Cervical Pain Treatment Chiropractic Care 05:08
  34. 34 18 Wheeler Accident Pain Treatment Chiropractor El Paso, TX 18 Wheeler Accident Pain Treatment Chiropractor El Paso, TX 02:23
  35. 35 Shoulder Pain Treatment El Paso, TX Chiropractor Shoulder Pain Treatment El Paso, TX Chiropractor 02:49
  36. 36 Back Pain Management El Paso, TX Chiropractor Back Pain Management El Paso, TX Chiropractor 05:51
  37. 37 Car Accident Injury Treatment El Paso, TX Chiropractor Car Accident Injury Treatment El Paso, TX Chiropractor 02:36
  38. 38 Auto Accident Injury Treatment El Paso, TX Auto Accident Injury Treatment El Paso, TX 02:15
  39. 39 Neck Pain Treatment El Paso, TX Chiropractor Neck Pain Treatment El Paso, TX Chiropractor 02:15
  40. 40 Slip And Fall Injury Treatment El Paso, TX Chiropractor Slip And Fall Injury Treatment El Paso, TX Chiropractor 01:55
  41. 41 *CHIROPRACTOR* The Most Recommended | El Paso, Tx (2019) *CHIROPRACTOR* The Most Recommended | El Paso, Tx (2019) 02:19
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